"Afterglow wireless headsets are compatible with Wii U. If the game chat utilizes the USB port of the Wii U console then the AG headset can receive the chat audio wirelessly. If the chat audio is directed through the 3.5mm audio jack on the Wii U pad then user can plug in the provided chat/game audio cable. It depends on how the game / chat audio is designed." - PDP rep

For example, that means Call of Duty: Black Ops 2 cannot be used with PDP's headset in wireless mode. This is more confusing than it needs to be!