I actually might agree with this selection; every time I've played this game, my hands have trouble, and fatigue quickly because of the control choice. A second pad would do wonders for me, but maybe just this once.

Kid Icarus: Uprising

Though many are looking forward to the 3D comeback of Pit, our excitement has been tempered by one niggling issue. We've played Kid Icarus: Uprising more times than we can count and every time we've walked away with hand cramps.
Yes, the Circle Pad is one of the great additions of the 3DS but when it comes to utilizing both it and wielding a stylus simultaneously, us left handed gamers are left struggling. With a second analogue located on the other side of the console, our fears of uncomfortable sessions of Kid Icarus: Uprising might be put to rest.

Source: GamerZines