The Legend of Zelda: Skyward Sword (Wii)
"Song of the Hero" Game-Killing Bug
Strike three, Nintendo. This is the third game on the Wii with a game-killing glitch. If you are unfortunate enough to stumble into this glitch, you're either going to have to start your game over, send your save file on an SD card to Nintendo to fix the problem, or modify the save file on your computer to remedy the problem. In an age where bugs can quickly be fixed through a patch, it's ridiculous that players have to go through loops and hurdles just to get their game back on track. After similar game-killing bugs found in Twilight Princess and Metroid: Other M, you think that Nintendo can get their shit together. Hopefully, the Wii U will be technologically advanced enough to support patches.
Considering that several other games on this list also have game-halting glitches, Skyward Sword's takes the top spot simply because of the poor method in order to fix it. The game-killing bug here occurs when you complete tasks in a certain order during the "Song of the Hero" quest. If you save the game after the bug is in effect, then prepare to start the game over.
If you complete the desert section of the quest first and talk to the Goron twice, the game locks out completion of the other two portions, halting all progress of the game. How do you avoid this? Just talk to the Goron guy once. Alternatively, don't do the desert section of the quest first.
Source: OC Weekly