Twitter: No.
Facebook: Functional, interesting, but also usless as I have a computer five feet away. With a keyboard.
Last FM.: Cool concept, would use it if Pandora wasn't better and on my computer. Last FM on the computer is most likely better as well. Also you can't use it in game. So...just *crag*ing use the built in music player which you can use in game instead.
So yeah. Who the *crag* does Microsoft think they are targetting again? Oh yes, the college crowd. You know, young people who use the 360 as their main media hub.
Because we all know college students don't have laptops.